Publications

Clippinger SR, Cloonan PE, Greenberg L, Ernst M, Stump WT, *Greenberg MJ. Disrupted mechanobiology links the molecular and cellular phenotypes in familial dilated cardiomyopathy. Proc Natl Acad Sci U S A. 2019 Sep 3;116(36):17831-17840. PMCID: PMC6731759. PMID: 31427533.
Lavine KJ, Greenberg MJ. Beyond genomics-technological advances improving the molecular characterization and precision treatment of heart failure. Heart Fail Rev. 2020 Sep 3. doi: 10.1007/s10741-020-10021-5. Epub ahead of print. PMID: 32885327
Greenberg MJ, Tardiff JC. Complexity in genetic cardiomyopathies and new approaches for mechanism-based precision medicine. Journal of General Physiology. 2021; Mar 1;153(3):e202012662. PMID: 33512404.
Bailey AL, Dmytrenko O, Greenberg L, Bredemeyer AL, Ma P, Liu J, Penna V, Winkler ES, Sviben S, Brooks E, Nair AP, Heck KA, Rali AS, Simpson L, Saririan M, Hobohm D, Stump WT, Fitzpatrick JA, Xie X, Zhang X, Shi PY, Hinson JT, Gi WT, Schmidt C, Leuschner F, Lin CY, Diamond MS, Greenberg MJ, Lavine KJ. SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis. JACC Basic Transl Sci. 2021 Apr;6(4):331-345. doi: 10.1016/j.jacbts.2021.01.002. Epub 2021 Feb 26. PMID: 33681537
Koenig AL, Shchukina I, Amrute J, Andhey PS, Zaitsev K, Lai L, Bajpai G, Bredemeyer A, Smith G, Jones C, Terrebonne E, Rentschler SL, Artyomov MN, Lavine KJ. Single-cell transcriptomics reveals cell-type-specific diversification in human heart failure. Nat Cardiovasc Res. 2022 Mar;1(3):263-280. doi: 10.1038/s44161-022-00028-6. Epub 2022 Mar 16. PMID: 35959412
Liu J, Ma P, Lai L, Villanueva A, Koenig A, Bean GR, Bowles DE, Glass C, Watson M, Lavine KJ, Lin CY. Transcriptional and Immune Landscape of Cardiac Sarcoidosis.Circ Res. 2022 Sep 30;131(8):654-669. doi: 10.1161/CIRCRESAHA.121.320449. Epub 2022 Sep 16.PMID: 36111531
Barrick SK, Garg A, Greenberg L, Zhang S, Lin CY, Stitziel NO, Greenberg MJ. Functional assays reveal the pathogenic mechanism of a de novo tropomyosin variant identified in patient with dilated cardiomyopathy. J Mol Cell Cardiol. 2023 Mar;176:58-67. doi: 10.1016/j.yjmcc.2023.01.014. Epub 2023 Feb 3. PubMed PMID: 36739943; PubMed Central PMCID: PMC11285302.
Amrute JM, Lai L, Ma P, Koenig AL, Kamimoto K, Bredemeyer A, Shankar TS, Kuppe C, Kadyrov FF, Schulte LJ, Stoutenburg D, Kopecky BJ, Navankasattusas S, Visker J, Morris SA, Kramann R, Leuschner F, Mann DL, Drakos SG, Lavine KJ. Defining cardiac functional recovery in end-stage heart failure at single-cell resolution.Nat Cardiovasc Res. 2023 Apr;2(4):399-416. doi: 10.1038/s44161-023-00260-8. Epub 2023 Apr 6.PMID: 37583573
Mitchell JD, Panni U, Fergestrom N, Toriola AT, Nywening TM, Goedegebuure SP, Jiang X, Mudd JL, Cao Y, Ippolito J, Fields RC, Hawkins WG, Peterson LR. Plasma Ceramide C24:0/C16:0 Ratio is Associated with Improved Survival in Patients with Pancreatic Ductal Adenocarcinoma. Ann Surg Oncol. 2024 Sep 21. doi: 10.1245/s10434-024-16245-1. Epub ahead of print. PMID: 39306621.
Garg A, Jansen S, Greenberg L, Zhang R, Lavine KJ, Greenberg MJ. Dilated cardiomyopathy-associated skeletal muscle actin (ACTA1) mutation R256H disrupts actin structure and function and causes cardiomyocyte hypocontractility. Proc Natl Acad Sci U S A. 2024 Nov 12;121(46):e2405020121. doi: 10.1073/pnas.2405020121. Epub 2024 Nov 6. PubMed PMID: 39503885.
Amrute JM, Luo X, Penna V, Yang S, Yamawaki T, Hayat S, Bredemeyer A, Jung IH, Kadyrov FF, Heo GS, Venkatesan R, Shi SY, Parvathaneni A, Koenig AL, Kuppe C, Baker C, Luehmann H, Jones C, Kopecky B, Zeng X, Bleckwehl T, Ma P, Lee P, Terada Y, Fu A, Furtado M, Kreisel D, Kovacs A, Stitziel NO, Jackson S, Li CM, Liu Y, Rosenthal NA, Kramann R, Ason B, Lavine KJ. Targeting immune-fibroblast cell communication in heart failure. Nature. 2024 Nov;635(8038):423-433. doi: 10.1038/s41586-024-08008-5. Epub 2024 Oct 23. PMID: 39443792
Greenberg L, Tom Stump W, Lin Z, Bredemeyer AL, Blackwell T, Han X, Greenberg AE, Garcia BA, Lavine KJ, Greenberg MJ. Harnessing molecular mechanism for precision medicine in dilated cardiomyopathy caused by a mutation in troponin T. bioRxiv. 2024 Apr 9;. doi: 10.1101/2024.04.05.588306. PubMed PMID: 38645235; PubMed Central PMCID: PMC11030379.
Scott B, Greenberg L, Squarci C, Campbell KS, Greenberg MJ. Danicamtiv reduces myosin’s working stroke but enhances contraction by activating the thin filament. bioRxiv. 2024 Oct 31;. doi: 10.1101/2024.10.09.617269. PubMed PMID: 39416013; PubMed Central PMCID: PMC11482770. (Under review at PNAS)